Methadone
Available Dosages: 40 mg Tablets
Imprints: “M 2540” “+”
Shape/Color: 4 sided Round, Orange
Manufacturers: Roxane Laboratories.
Buy methadone online. Methadone, sold under the brand name Dolophine among others, is an opioid used for opioid maintenance therapy in opioid dependence and for chronic pain management. Detoxification using methadone can be accomplished in less than a month, or it may be done gradually over as long as six months.
Side effects are similar to those of other opioids. These frequently includes dizziness, sleepiness, vomiting, and sweating. Serious risks include opioid abuse and a decreased effort to breathe. Abnormal heart rhythms may also occur due to a prolonged QT interval.
The number of deaths in the United States involving methadone poisoning declined from 4,418 in 2011 to 3,300 in 2015. Risks are greater with higher doses. Methadone is made by chemical synthesis and acts on opioid receptors.
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Methadone : (methadone hydrochloride) Oral Tablets, USP
DESCRIPTION
Methadone hydrochloride is chemically described as 6-(dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride. Methadone hydrochloride is a white, crystalline material that is water-soluble. Methadone hydrochloride has a melting point of 235°C, and a pKa of 8.25 in water at 20°C. Its octanol/water partition coefficient at pH 7.4 is 117. A solution (1:100) in water has a pH between 4.5 and 6.5.
Methadone Oral Tablets (methadone hydrochloride tablets USP) each contain 5 or 10 mg of methadone hydrochloride, USP and the following inactive ingredients: dibasic calcium phosphate, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, pregelatinized starch, and stearic acid.
INDICATIONS
Methadone Oral Tablets (methadone hydrochloride) Tablets, USP) are indicated for the:
-Management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.
-Detoxification treatment of opioid addiction (heroin or other morphine-like drugs).
-Maintenance treatment of opioid addiction (heroin or other morphine-like drugs), in conjunction with appropriate social and medical services.
Limitations of Use
Methadone is not for use:
-As an as-needed (prn) analgesic
-For pain that is mild or not expected to persist for an extended period of time
-For acute pain
-For postoperative pain
Initial Dosing for Management of Pain:
Consider the following factors when selecting an initial dose of Methadone:
-Total daily dose, potency, and prior opioid the patient has been taking previously;
-Patient’s degree of opioid experience and opioid tolerance;
-General condition and medical status of the patient;
-Concurrent medication;
-Type and severity of the patient’s pain
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Dosage Forms And Strengths
Methadone Oral Tablets (methadone hydrochloride tablets USP) is available in 10 mg dosage strengths. The 10 mg tablets are white, scored tablets (Identified METHADONE 10).
Storage And Handling
Methadone contains methadone which is a controlled substance. Like fentanyl, morphine, oxycodone, hydromorphone, and
oxymorphone, methadone is controlled under Schedule II of the Federal Controlled Substances Act. Methadose may be targeted for theft and diversion by criminals [see WARNINGS AND PRECAUTIONS].
Keep tightly closed. Dispense in a tight, light-resistant container.
Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].
How Supplied
Methadone Oral Tablets (methadone hydrochloride tablets USP):
10 mg white, scored tablets (Identified METHADOSE 10)
